Faulty DNA samples are derailing efforts A man discovered the severed head of a woman on June 12, 1993, in New Scandia Township's Bone Lake. Two decades later, her identity remains a mystery.

This chimera induces DSBs specifically at replication forks, allowing the researchers to study the repair mechanisms involved. The study found that core homologous recombination (HR) proteins, which ...

Summary: Researchers have discovered that the protein USP50 regulates DNA replication by managing which enzymes—nucleases or helicases—cleave or unwind DNA strands during replication.This control is ...

In a new paper published in Nature Communications, an international team of researchers have found that the protein USP50 supports the DNA replication process by helping to decide the proper use ...

New research shows that DNA replication in early mouse embryos doesn't follow the expected patterns seen in older cells. ... Further testing suggested that the copying errors at this stage were ...

Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression. EMBO Reports , 2024; DOI: 10.1038/s44319-024-00207-5 Cite This Page : ...

In mammalian cells, tens of thousands of DNA replication origins are activated in the S phase to start genomic duplication. Each origin must be ‘fired’ only once to prevent DNA over-replication and ...

The completion of DNA synthesis is crucial for maintaining genome stability and survival but a variety of obstacles to DNA replication have the ability to stall replication forks (Magdalou et al., ...

A key part of the intricate DNA replication machinery is a molecular motor called CMG, which has the vital task of separating the two strands of the DNA double helix so that they can be copied. An ...