Therefore, DNA lesions cause regions of DNA to remain single-stranded (uncopied). Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted.

Animation of DNA’s knot-like i-motif structure the team mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene activity Credit ...

Secondary structures, highly transcribed DNA sequences and damaged DNA stall replication forks, which then require checkpoint factors and specialized enzymatic activities for their stabilization ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

The human body is a remarkably complex machine, so it would make sense that it houses an abundance of DNA – the blueprints that help guide the body's growth and repair. But how much DNA do our ...

DNA microarrays are normally used to detect variation in mRNA abundance. But in the August 15 Proceedings of the National Academy of Sciences Khodursky et al. use the arrays to track the progress of ...

In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two replication forks are established that travel in ...

Chances are you've seen an illustration of DNA's double-helix structure and even pictures of the chromosomes that comprise the human genome. But where and how does the famous double helix fit into ...

"We propose that slow replication forks are not the manifestation of replication impediments but rather an integral feature of DNA replication in ES cells. Our study underscores the dynamic ...