Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive tolerability profile, expected PK/PD activity, and promising clinical signals ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data ...

Abstract: Protein-DNA interactions are pivotal to numerous cellular processes, including DNA replication, and repair. Accurate prediction of these interactions is essential for understanding ...

DNA replication is one of the most well-orchestrated cellular processes that needs to proceed in a faithful and timely manner. However, this process is continuously challenged, leading to stalled ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

A new study has identified USP50, a protein that helps regulate enzymes during DNA replication, ensuring proper use of nucleases and helicases. The discovery sheds light on how cells manage ...

Scientists at the University of Vienna have achieved a significant milestone in DNA technology, introducing a breakthrough that expands the color spectrum available for DNA-based images. Traditionally ...

Scientists have developed a way to “paint” with DNA, creating 16 million colors to accurately reproduce digital images with 24-bit color depth. The resulting images are incredible, and represent not ...