So why would normal cells need ATR? There are other circumstances that cause replication to go awry. One is that the DNA template somehow becomes defective during replication, and causes the ...

According to the conservative replication model, the entire original DNA double helix serves as a template for a new double helix, such that each round of cell division produces one daughter cell ...

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous ... after a successful search ...

DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division. The double helix unwinds, and each strand serves as a template for the synthesis of a new ...

In addition, we have recently begun to ask how cell cycle events including DNA replication and chromosome segregation are coupled to cellular ... We are examining cis- and trans-acting factors, ...

During DNA replication, the complementary base pairing of thymine with adenine ensures the accurate copying of genetic information. DNA polymerase enzymes use the existing DNA strand as a template and ...

Through this approach, we aim to understand how faithful and efficient chromosomal DNA replication is achieved under normal conditions and, conversely, how the replication machinery is affected by and ...

the presence of an organism’s own genetic code—in the form of complementary DNA (cDNA) synthesized from an RNA template—has puzzled scientists. In each case, the cDNA has come from endogenous ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...