One is that the DNA template somehow becomes defective during replication, and causes the polymerase to pause (Figures 3 and 4a). For example, a DNA base can be chemically modified or ...

Credit: Kateryna Kon/Science Photo Library/ What is DNA, and how does it work? You don't need a degree in genetics to understand. Here, we'll give an overview of DNA and answer questions ...

Sandra Small, senior manager of science education and workforce development, is Co-I on a $2.45 million R01 grant from the National Institute of General Medical Sciences that will fund exploration of ...

Posted: Aug 31, 2006: DNA as template for assembling nanostructures (Nanowerk Spotlight) Recent developments in DNA-based nanotechnology have shown the suitability of this novel assembly method for ...

And one of the things it can get stuck on is the DNA template itself, ... gained attention as potential therapeutic targets ...

DNA replication and repair are critical processes that ensure the correct genetic material of a biological system is carried on. DNA continually undergoes a process of replication and division and ...

Cryo-electron microscopy reveals hidden mechanics of DNA replication, sheds new light on cancer target Date: March 10 ... And one of the things it can get stuck on is the DNA template itself, ...

And one of the things it can get stuck on is the DNA template itself, which can adopt alternative structures in certain contexts. For example, regions of the genome that are rich in guanine bases ...

DNA replication is an essential part of cell division. ... “While replication stress can be driven by various factors, the most common internal source is the DNA template itself. Our work shows that ...

But if the proton does not make it back by the time the two DNA strands separate—the first step of DNA replication—the cytosine might bind to a different base, adenine, rather than guanine ...