The faithful recovery of the base sequence in automatic DNA sequencing fundamentally depends on the underlying statistics of the DNA electrophoresis time series. Current DNA sequencing algorithms are ...

When normal DNA repair systems are broken, as in BRCA-deficient cancers, cells rely on backup proteins like RAD52 to keep growing. If RAD52 is blocked, the cancer cells can’t fix their DNA and die.

Combined genetic and biophysical characterisation establishes that structure stability and probability of structure formation are key determinants of replisome arrest. Mechanistically, replication ...

Figure 1: Overview of the IDEA protocol. The protein–DNA complex, represented by the human MAX–DNA complex structure (PDB ID: 1HLO), was used for training the IDEA model. The sequences of the protein ...

Decoding the Spin Patterns in DNA “Our research has unveiled the patterns of the principal axis directions of the electric field gradient at the nitrogen atom sites in DNA molecules, demonstrating ...

Neandertal DNA may affect the color of our skin and hair, how readily our blood clots, our propensity for heart disease, and how our cells respond to various environmental stressors such as radiation.

The researchers were focusing on i-motif DNA, which has an interlocking structure resembling a knot, and was only confirmed to be found in living human cells in 2018. Dr. Waller said: “It was ...

Arrays of gene variants in Thorin’s DNA more closely align with the previously reported DNA structure of Neandertals that lived around 105,000 years ago, versus Neandertals dating to around ...

The UCL School of Pharmacy has a long history of characterisation of alternative DNA structures, from the first crystal structure of a different DNA structure called a G-quadruplex, in a 2011 ...

DNA is widely accepted to be formed of two strands that wind around one another, known as a double helix, but it is possible for DNA to change shape and structure. The new study, published in ...