In an interview with Technology Networks, Dr. Daniel Reker discusses how machine learning is improving data-scarce areas of drug discovery.

依托DrugCLIP，联合团队首次完成了人类基因组规模的虚拟筛选项目，可覆盖约1万个蛋白靶点、2万个蛋白口袋，分析筛选超过5亿个类药小分子，总共富集出超过200万个潜在活性分子，构建了目前已知最大规模的蛋白-配体筛选数据库，该数据库已免费面向全球科研社区开放，为基础研究与早期药物发现提供了强大数据支持。

对于严重心理疾病的患者，迷幻剂辅助治疗是一种有效手段。迷幻剂可以激发患者的强烈体验与自我反思，从而打破抑郁、成瘾等患者长期固化的思维与情绪模式，为心理治疗创造“突破窗口”。然而，真实迷幻剂的使用伴随着安全风险、伦理争议和严格监管。1月16日发表在 ...

Forensic science has long held that fingerprints are singular identifiers, unique to each finger and each individual. This ...

人类基因组由约2万个编码蛋白质的基因组成。目前，这些基因中仅有约10%发现了靶向小分子，这意味着大量疾病缺少有效的治疗手段。 清华大学 在1月8日的《科学》杂志上报告了一项突破性成果，研究者首先使用 AlphaFold ...

在湿式实验室验证中，DrugCLIP实现了15%的去甲肾上腺素转运蛋白命中率，并且在与靶蛋白的复合物中确定了两种已鉴定抑制剂的结构。对于甲状腺激素受体相互作用因子12，一种缺乏全结构和小分子结合物的靶标，DrugCLIP仅使用AlphaFold2预测结构就达到了17.5%的命中率。最后，研究人员发布了GenomeScreenDB，这是一个开放的数据库，提供了针对5亿种化合物筛选的约10，000种人 ...

You will be redirected to our submission process. Cervical cancer detection and diagnosis are undergoing a transformation with the integration of advanced deep learning (DL) technologies. Despite ...

The efficacy of deep residual networks is fundamentally predicated on the identity shortcut connection. While this mechanism effectively mitigates the vanishing gradient problem, it imposes a strictly ...

There's something interesting happening with the celebrities we've known, loved, and followed for decades: They don't seem to be aging like the rest of us. Lindsay Lohan, at the height of her ...

The identification of wheat infections has always been a considerable problem in agricultural forecasting. This paper presents an automated classification framework for wheat illnesses utilising ...

Abstract: In the context of industrial bearing prognostics, conventional deep learning methods have demonstrated remarkable prediction capabilities but typically provide only deterministic remaining ...