Myopathy refers to diseases of skeletal muscles (muscles connected to bone). The condition can be acute (meaning sudden, severe, and short-lasting) or chronic (persistent, recurrent, and often ...

An acute necrotising myopathy is a distinct form of uncommon muscle disease characterised by the rapid advancement of ...

We studied five patients from two families from the United States of America. In family CSM1, two out of three siblings developed proximal muscle weakness and wasting while in their twenties or ...

A number of proteins regulating this process are mutated in human diseases. We focus on centronuclear myopathy due to mutations in the large GTPase dynamin 2 (DNM2), the first protein shown to ...

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. (B.A., B.M., S.A.M., C.T., A.G., R.T.C., H.C., C.A.J., A.S ...

Distal weakness, mostly affecting the small hand muscles, generally an extremely rare presentation of myopathy, was identified in several patients with IBMPFD. Approximately half of our patients ...

The evidence supporting the efficacy of exercise therapy for patients with PAD dates back to 1966 when 6 months of unsupervised intermittent walking exercise was demonstrated to improve time walked to ...

Clinicians should be aware that there is a low risk of inadvertent penetration of the distal interphalangeal joint ... the response to extracorporeal shockwave therapy and physical rehabilitation in ...

8 The possibility of a diagnosis of DM2—previously known as proximal myotonic myopathy—should also be given consideration. DM2 is characterized by proximal and distal weakness associated with ...

In the mild and moderate stages of dementia abnormal gait unexplained by lower-level disorders (such as arthritis, polyneuropathy, radiculopathy, myopathy ... in the distal parts of the limbs ...

1 Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK 2 Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK 3 Gastroenterology Unit, John ...

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For ...