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本研究针对滤泡性淋巴瘤(FL)中V-ATPase突变导致溶酶体/液泡脱酸化却意外激活自噬的现象，通过酵母模型发现V-ATPase依赖的自 ...

本综述系统阐述了分子马达（kinesins、dynein、myosins）在胰岛β细胞胰岛素分泌颗粒（ISGs）运输及葡萄糖刺激胰岛素分泌（GSIS）中的核心作用，揭示了其通过直接调控颗粒运输与间接影响微管网络构建、钙通道空间分布及线粒体定位等机制精细调节分泌过程，并为 ...

Using single-cell transcriptomic data from adult mouse inner ear hair cells, the authors identify the differences and similarities of the four hair cell types. They make an important finding: that ...

ABSTRACT: Vacuolar H⁺-ATPase (V-ATPase), encoded by the ATP6V gene family, is an evolutionarily conserved, a multisubunit proton pump that plays a fundamental role in maintaining intracellular pH ...

Program of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States Medical Scientist Training Program, University of Massachusetts Medical School, ...