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综述:细菌颠覆自噬体-溶酶体融合作为保守的免疫逃逸策略
本综述系统阐述了细菌病原体通过靶向自噬体-溶酶体融合这一关键步骤实现免疫逃逸的保守策略。文章深入解析了其三大分子机制:破坏RAB GTPases功能、干扰HOPS与SNARE复合物、抑制溶酶体生物发生与定位,并探讨了通过恢复自噬流(autophagic flux)以增强宿主免疫 ...
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