Efficacy of high-dose alkylating chemotherapy in the adjuvant treatment of HER2/neu-negative primary breast cancer: Update of the Dutch Randomized Trial ...

Anna J. Khalaj, JaeHee Yoon, Jaspreet Nakai, Zachary Winchester, Spencer M. Moore, Timothy Yoo, Leonardo Martinez-Torres, Shalini Kumar, Noriko Itoh, Seema Kaushalya Tiwari-Woodruff Proceedings of the ...

The clinicopathologic importance of a second estrogen receptor (ER), ER-β, in breast cancers has been intensely studied; however, there is still no real consensus regarding the clinical utility of an ...

Injury to the enteric nervous system (ENS) can cause several gastrointestinal (GI) disorders including achalasia, irritable bowel syndrome, and gastroparesis. Recently, a subpopulation of enteric ...

SAN ANTONIO – Among patients with hormone receptor-positive breast cancer treated with an aromatase inhibitor plus palbociclib (Ibrance), those who displayed a rising ESR1 mutation detected in their ...

Systemic lupus erythematosus is a chronic autoimmune disease in which immune cells invade various organs and unleash harmful inflammatory responses. Estrogen may contribute to the condition, which ...

Scientists at University of California and University of Illinois have disclosed compounds acting as estrogen receptor β (ER-β; ESR2) ligands reported to be useful for the treatment of endometriosis, ...

Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth ...

Roche has reported a phase 3 win for its oral selective estrogen receptor degrader (SERD), bouncing back from an earlier setback to deliver data that could support filings for approval in breast ...