A total of 624 patients underwent randomization; 313 were assigned to receive vepdegestrant, and 311 to receive fulvestrant. Among the 270 patients with ESR1 mutations, the median progression-free ...

Reference: Nishide G, Ishibashi T, Lim K, et al. Zooming into gene activation: estrogen receptor α dimerization and DNA binding visualized by high-speed atomic force microscopy. ACS Nano. 2025;19 (16) ...

Estrogen receptor alpha (ERα), a key nuclear hormone receptor, plays a central role in mediating estrogen’s effects in the female reproductive system. ERα is predominantly expressed in tissues, such ...

Estrogen binds to receptor sites in your liver, affecting the genes involved in lipid metabolism and their expression. Lipid metabolism controls the way your body breaks down, stores, and utilizes ...

Most breast cancers are estrogen receptor-positive (ER+), meaning the cells grow in response to estrogen. However, not all breast cancers are ER+, and some do not respond to estrogen.

Most breast cancer risk factors are associated with prolonged exposure of the mammary gland to high levels of estrogens. The actions of estrogens are predominantly mediated by two receptors, ERα and ...

Estrogen Modulators Compounds that act as “modulators” can attach to the estrogen receptor to change its activity. For example, SERMs are modulators for some estrogen receptors—turning up or down the ...

To know whether specific chemical compounds can interfere with bodily functions that might have a negative impact on health, scientists have developed an effective bagging-based ensemble model for ...

Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the ...

The use of vaginal estrogen therapy (VET) increased the risk for breast cancer recurrence by 39% in women with early estrogen receptor–positive breast cancer who were taking aromatase inhibitors ...