The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II ...

Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem 1998;273:29321-29330. Crossref. PubMed. Web of Science. Google Scholar. 57.

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

The selective estrogen-receptor modulators, or SERMs, chemically diverse nonsteroid compounds, have tertiary structures that permit binding to the estrogen receptor. These compounds have either sel ...

Methods: ERα ChIP-seq data from proliferating MCF-7 breast cancer cells was used from a publically available dataset [Ross-Innes, 2010]. The transcription start sites of the 58 genes in the gene set ...

e15647Background: Antiestrogens are a mainstay of treatment for estrogen receptor positive (ER+) breast cancer in both the adjuvant and the advanced/metastatic settings. ... (RAD1901), a novel ...

Discover how high-speed AFM reveals estrogen receptor binding to DNA, enhancing understanding of gene regulation. ... Lim K, et al. Zooming into gene activation: estrogen receptor α dimerization and ...

"We have shown that a couple of compounds are good estrogen receptor binders in vitro, meaning they could inhibit estrogen from binding to its receptor," says Koffas, "so if further testing in ...

Because estrogen receptor binders can prevent cancer-causing compounds from binding to estrogen, they may be able to thwart the growth of cancerous tumors. Koffas says that they were able to achieve ...

When estrogen binds to receptor sites in cancer cells, it makes them grow. Tamoxifen works by sitting on the estrogen receptors in breast tissue. This prevents estrogen from binding to the cancer ...

Estrogen has been shown to promote neuronal survival in such models of Parkinson’s, thought to be due to estrogen's ability to interfere with dopamine binding for reuptake at presynaptic sites ...