In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin. Cancer Res. 4 , 2925–2929 (1998).

The estrogen-receptor–ligand complex also leads to binding of various coregulator proteins that vary with its conformational structure. Some estrogen-receptor–SERM complexes favor corepressor ...

The presence of specific, high-affinity estrogen binding in nonnuclear subcellular fractions, including plasma membrane and mitochondria, implies that the estrogen receptor could be located at ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

HER2 tumor marker tests are used to determine whether breast cancer is HER2 positive or negative. A person is a candidate for ...

Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research. The nuanced findings may help explain why dogs spayed at a young age are more likely ...

In this section, we review key current topics in the management of estrogen receptor–positive breast cancer. We review therapeutic options that may reduce the risk of late relapse, how to optimally ...

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives. Acta Materia Medica. 2024. Vol. 3(1):57-71. DOI: 10.15212/AMM-2024-0006. DOI.

To study the function of this new variant, they stably transduced and overexpressed ERα36 in human embryonic kidney cells (HEK293), which do not express the receptor. 2 They showed that ERα36 lacks ...