Their study, published recently in Nature, focuses on what is known as the estrogen receptor, a protein linked ... used small-angle X-ray scattering and nuclear magnetic resonance spectroscopy ...

Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes.

This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth ...

SRC1 was the first cloned steroid receptor ... in a hormone-dependent manner. The p160 SRC family contains three homologous members, SRC1, SRC2 and SRC3, that interact with nuclear receptors ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

Over time, levels of the hormones testosterone and estrogen can become imbalanced in males, potentially causing health problems. Medications called estrogen blockers are among the treatment options ...

Prior to menopause, natural estrogen production helps decrease the risk of a heart attack. After menopause, though, estrogen levels fall, and by age 60 to 65, men and women have approximately the same ...

These include nuclear import, intranuclear targeting ... is modified in AML as a result of chromosomal translocations (that is, t(8;21)). Yet another example of architectural reorganization ...

1Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

Journal of Nuclear Medicine January 2025, jnumed.124.269268; DOI: https://doi.org/10.2967/jnumed.124.269268 ...

Oct. 17, 2024 — Researchers have developed strategies to identify regulators of intestinal hormone secretion. In response to incoming food, these hormones are secreted by rare hormone producing ...