Estrogen's direct genomic effects are mediated by the nuclear form of the estrogen receptors ERα or ERβ which associate with the Estrogen Response Element (ERE) or the fos/jun heterodimers that bind ...

Thyroid hormones (T) and estrogens (E) are nuclear receptor ligands with at least two molecular mechanisms of action: (i) relatively slow genomic effects, such as the regulation of transcription by ...

Estrogen signaling was responsible for immunosuppressive effects in the tumor microenvironment across cancer types, a new study has concluded. These findings pave the way for combining ...

A team of researchers led by Baylor College of Medicine found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, but neither do ...

This is a preview. Log in through your library . Abstract Nuclear receptors can activate diverse biological pathways within a target cell in response to their cognate ligands, but how this ...

As expected, they found that estrogen activated GREB1 and MYC genes quickly, within 15 minutes, but there was an unexpected and marked asynchronous response to hormone simulation at both the ...

Studying alternate realities has traditionally been the purview of physicists, cosmologists, and philosophers. Maybe theologians. But at the University of Chicago, biochemists, molecular biologists, ...

Aging is a natural process of mental and physical change. During adolescence, for example, the accelerated development of the body coincides with the psychological stress and volatility of the ...

Researchers found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies, known as alleles. A team led by ...