Estrogen's direct genomic effects are mediated by the nuclear form of the estrogen receptors ERα or ERβ which associate with the Estrogen Response Element (ERE) or the fos/jun heterodimers that bind ...

Thyroid hormones (T) and estrogens (E) are nuclear receptor ligands with at least two molecular mechanisms of action: (i) relatively slow genomic effects, such as the regulation of transcription by ...

A team of researchers led by Baylor College of Medicine found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, but neither do ...

This is a preview. Log in through your library . Abstract Nuclear receptors can activate diverse biological pathways within a target cell in response to their cognate ligands, but how this ...

Know someone who's been diagnosed with breast cancer? There's a good chance that person has received hormone therapy. Estrogen receptor-positive (ER+) breast cancers account for about 75% of cases.

As expected, they found that estrogen activated GREB1 and MYC genes quickly, within 15 minutes, but there was an unexpected and marked asynchronous response to hormone simulation at both the ...

Low circulating testosterone in older men is linked to an increased risk for Alzheimer disease (AD), suggesting that the hormone somehow protects the brain. But is it really the testosterone that ...

Researchers found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies, known as alleles. A team led by ...