The present study demonstrates modulatory actions of estrogen in transactivations of SXR-mediated liver X receptor response element (LXRE) and CAR-mediated phenobarbital response element (PBRU).

A BUSY HORMONE:© 2001 Annual ReviewsEstrogen's direct genomic effects are mediated by the nuclear form of the estrogen receptors ERα or ERβ which associate with the Estrogen Response Element (ERE) or ...

These estrogen–estrogen receptor complexes bind to specific sequences of DNA called estrogen-response elements as homodimers or heterodimers. 31 The estrogen–estrogen receptor complexes bind ...

The findings suggest that estrogen plays a protective role against opioid misuse in the context of chronic pain by reducing the brain’s response to the drug. Understanding how pain and hormones ...

Transactivation of an ERE-LUC (estrogen-response element upstream of luciferase) construct in transfected COS-7 cells revealed greatly reduced activity in the mutated estrogen receptor, as ...

Estrogen signaling was responsible for immunosuppressive effects in the tumor microenvironment across cancer types, a new study has concluded. These findings pave the way for combining ...

The DNA sequence that the estrogen receptor binds—called the estrogen response element—differs from the DNA sequence that the more generic steroid receptor sticks to, though only in two locations.

However, a small molecule inhibitor of selected estrogen coregulators increased the response of individual alleles to hormone, establishing a previously unrecognized mode of regulation of ...

Estrogen-bound estrogen receptor (ER), in complex with coactivators (CoA) or corepressors (CoR), regulates target gene expression via the estrogen response element (ERE) or the AP1 binding sites via ...

Wistar Institute scientists have found that, in addition to driving breast and ovarian cancer growth, the hormone estrogen plays a role in tamping down the immune response against various cancers.

Surprisingly, BACE expression was lower. The BACE gene contains an estrogen response element that suppresses expression, making Li expect increased BACE expression sans estrogen, if anything. “We ...