R-loops consist of double-stranded DNA-RNA hybrids and a complementary DNA strand that is displaced from the duplex. R-loops play important role in numerous normal physiological processes, including ...

This Research Advance manuscript further elucidates the roles of SMC5/6 loader proteins and associated factors in the silencing of extrachromosomal circular DNA by the SMC5/6 complex. While the ...

2Group of Theoretical Biology, Innovation Center for Evolutionary Synthetic Biology, School of Life Science, Sun Yat-sen University, Guangzhou, China. 17Centre for Dynamics Systems, School of ...

DNA catenanes are molecular structures composed of two interlocked circular DNA molecules, held together by a mechanical bond─a topological constraint arising from their mutual interlocking. Using all ...

Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.

Aging and Cardiovascular Discovery Center (C.G., M.C., V.M., C.B., D.J., C.T., Z.C., M.T., A.K.R., V.N.S.G., R.K.), Lewis Katz School of Medicine, Temple University ...

Scientists in Tokyo have uncovered “Inocles,” massive strands of extrachromosomal DNA hidden inside bacteria in human mouths. These giants, overlooked by traditional sequencing, could explain how oral ...

While scientists are amassing a fair amount of data regarding our gut microbiomes, the oral microbiome is a bit of a new frontier. Case in point: researchers have just discovered huge pieces of DNA ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

There are over 100 types of human papillomavirus (HPV), and some can lead to different types of cancer, including cancer that affects the nose and throat. These are known as HPV-associated ...

Neuroblastoma can be a particularly insidious cancer. In about half of all cases, tumors regress, even without therapy. In the other half, tumors grow very quickly. These tumors often respond well to ...