16. Browning JD and Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. (2004) 114:147–52. doi: 10.1172/JCI200422422 Crossref Full Text | Google Scholar ...

1 School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China 2 School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China 3 Academy of Chinese ...

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Molecular pathways involved with dietary restriction, metformin or rapamycin. Arrows imply activation; bars denote inhibition. Figure designed by ZS using BioRender.com. Credit: Aging Cell (2025).

It works by blocking a molecular switch that tells cells when nutrients are abundant. Metformin, meanwhile, is a synthetic descendant of a compound found in French lilac (also known as goat’s rue) and ...

But this drug, extracted from obscure soil bacteria, shows us that interfering with a single molecular pathway can be enough to mimic the benefits of eating less.

The discovery could be used to produce therapies that make humans healthier for longer without compromising quality of life ...

A molecular pathway has been identified in the regulation of unjamming to overcome cancer cell migration and proliferation arrest leading to collective cell invasion.

The accumulation of mitochondrial precursor proteins in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. Why non-imported precursors are ...

For centuries, humans have searched for ways to extend life. Alchemists never found the philosopher’s stone, but scientists have consistently shown that a longer life can be attained by eating ...

In fact, another drug that blocks the function of this molecular pathway, in addition to others, has already been tested in patients with myelodysplastic syndrome to induce cancer cell death “which ...