The idea for a conditional pathway for rare disease drugs is not new, he said, noting that former acting FDA Commissioner Janet Woodcock has also advocated for such an initiative. In 2016, Woodcock ...

In ovarian cancer, FSH upregulates OCT4 expression via the ERK1/2 signaling pathway, contributing to tumor progression (Liu et al., 2015). Elevated OCT4 promotes ovarian cancer cell proliferation and ...

Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. In the mammalian central nervous system, the atypical ligand Norrin ...

Scientists discover a new signaling pathway and design a novel drug for liver fibrosis. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 04 / 240426110048.htm ...

XJCRTSZW promotes mitophagy via the in-vivo PINK1/Parkin signaling pathway Transmission electron microscopy showed many swollen mitochondria in GCs with broken, dissolved, or even disappeared cristae, ...

Discovery of cross-species signaling pathway unlocks mysteries around parasite immunity and development Ticks recognize a cytokine from infected mammalian blood, triggering a defense against Lyme ...

Summary: The direct phosphorylation of KCNQ2 by ERK occurs through the activation of the dopamine signaling pathway in the nucleus accumbens of mice. Source: Fujita Health University One part of the ...

Previous research finds that women are twice as likely as men to develop Alzheimer’s disease (AD), but the cause of this phenomenon has been unclear. In a new study from the Chinese Academy of ...

FSH was linked to the development of Alzheimer’s, as male mice injected with FSH showed more evidence of Alzheimer’s pathologies. Overall, this work strongly shows increased FSH during menopause binds ...

The researchers employed different methods to demonstrate this finding. Using ovariectomized mice, they used anti-FSH antibody treatment to block FSH and inactivate the C/EBPβ/AEP pathway.

Scientists are gaining a new understanding of a key signaling pathway in embryo development, tissue maintenance, and cancer genesis. [Chepko/Getty Images] Researchers at the University of Illinois ...