基因的微小差异如何变成疾病、耐药等复杂表型？这是生命科学领域困扰百年的“基因型-表型鸿沟”—尽管基因组测序已普及，但大多数自然变异功能仍不明确。 2025年10月9日，斯坦福大学Daniel F.

This important study provides a systematic investigation of parent-of-origin (POE) effects on gene expression using large trio-based data from the Framingham Heart Study, uncovering thousands of ...

The federal government has been—and must remain—a critical partner in foundational technological innovation and research ...

审校 小勺 小象 小冰制版 阿金生物学BiologyMTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonistsMTAP缺乏阻断胞浆核酸感知并对STING激动剂产生抗性（导读 阿金）胞浆核酸感知通路是癌症免疫治疗的潜在靶点。甲硫腺苷磷酸化酶（MTAP）的缺失是人类肿瘤中的常见基因变化。