基因的微小差异如何变成疾病、耐药等复杂表型？这是生命科学领域困扰百年的“基因型-表型鸿沟”—尽管基因组测序已普及，但大多数自然变异功能仍不明确。 2025年10月9日，斯坦福大学Daniel F.

审校 小勺 小象 小冰制版 阿金生物学BiologyMTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonistsMTAP缺乏阻断胞浆核酸感知并对STING激动剂产生抗性（导读 阿金）胞浆核酸感知通路是癌症免疫治疗的潜在靶点。甲硫腺苷磷酸化酶（MTAP）的缺失是人类肿瘤中的常见基因变化。

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