Background Chronic stress is a known risk factor for cancer metastasis. However, the underlying mechanisms, particularly ...

N-亚硝胺类化合物是国际癌症研究机构认定的2A类致癌物 [1]。这类物质能够直接损伤细胞DNA，诱发基因突变，进而促进肿瘤形成。由于其较强的毒性，ICH M7将之列为“关注阵列”物质 [2]。在人用药品中，处方、工艺、包材、生产和贮藏环境等因素均可能导致N-亚硝胺类杂质的产生， 原料药 中出现N-亚硝胺类化合物与 原料药 自身制备过程，以及 溶剂 ...

本研究创新性地联用高效液相色谱（HPLC）与电感耦合等离子体原子发射光谱（ICP-AES）及电喷雾电离质谱（ESI-MS）技术，成功解析了金(I)氟化苯硫酚盐（H[Au(SR)2]）动态平衡体系中二硫化物、Au(I)物种[AuI(SR)2]-及Au(III)物种[AuIII(SR)4]-的共存现象。该联用策略通过色谱 ...

本研究针对山楂(Crataegus spp.)采后贮藏中易受印度谷螟(Plodia interpunctella)和赤拟谷盗(Tribolium castaneum)侵染导致品质下降的问题 ...

This paper reports an HPLC-ESI-MS/MS investigation on the oxidation of 3,5- and 4,5- dicaffeoylquinic acid using iron(III) tetraphenylporphyrin chloride as catalyst. Two major mono-oxidised products ...

High-performance liquid chromatography-mass spectrometry (HPLC-MS) combines the separation power of LC with the detection specificity of MS. It has become an indispensable analytical tool in the ...

Food safety is a widespread global concern with the emergence of foodborne diseases. Thus, establishing accurate and sensitive detection methods of harmful contaminants in different food matrices is ...

Thus, the aim of this work was to develop and apply a quantitative HPLC-ESI-MS/MS method to detect and quantify selected flavonoids in different botanical matrices, and to use this quantitative ...