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The N -glycans were released from the biomolecular corona using a LudgerZyme PNGaseFkit. For LC-ESI-MS and MS/MS analysis, procainamide labeled samples and system suitability standards were analyzed ...
Understanding how the presence of treatment relates to lipid profiles can provide more information regarding the assessment of the response to treatment. The mass spectra presented below (Figures 1 ...
编辑推荐: 为解决抗糖尿病药物联合用药监测难题,研究人员开发了一种基于高效液相色谱-电喷雾串联质谱 (HPLC-ESI-MS/MS)的检测方法,成功实现K3EDTA人血浆中二甲双胍 (MET)和维格列汀 (VLG)同步定量。
所开发的LC-MS分析方法可直接鉴定混合物中的降解物,避免了传统分离纯化的繁琐流程。 这些发现不仅完善了拉呋替丁的质量控制标准,其研究范式(HPLC-UV结合LC-ESI-MS)更为复杂药物分子的降解研究提供了技术蓝本。