Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic ...

Metabolic-dysfunction-associated steatotic liver disease (MASLD) arises from excessive intrahepatic triglyceride accumulation ...

Further analysis showed that Asah1 deficiency increased harmful lipids accumulation, disrupted lipid metabolism ... by regulating hepatic lipid homeostasis and cellular maintenance processes.

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

The fate of some of the IDL particles requires them to be reabsorbed by the liver (again by the LDL receptor); however, other IDL particles are hydrolyzed in the liver by hepatic-triglyceride ...

In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) are increasingly recognized as interrelated conditions with significant implications for ...

Discover preclinical studies that indicate that empagliflozin reduces liver fat, improves liver function markers, and ...