Scientists have described for the first time a key inhibitory role for the IL-1 signaling pathway in the human innate immune system, providing novel insights into human inflammatory bowel disease ...

Scientists at the University of California, San Diego School of Medicine have described for the first time a key inhibitory role for the IL-1 signaling pathway in the human innate immune system ...

New findings have established a unique TRAF6-independent signaling pathway activated by IL-17 (left). IKKi is recruited to the IL-17R–Act1 complex, where it specifically phosphorylates Act1 at ...

"With the most detailed mapping of neuronal IL-1R1 expression in the mouse brain to date, this study brings an unprecedented level of clarity to how IL-1 signaling impacts the neural circuits that ...

PALO ALTO, Calif.--(BUSINESS WIRE)--Genascence Corporation (“Genascence”), a clinical-stage biotechnology company revolutionizing the treatment of prevalent musculoskeletal diseases with gene ...

There was no significant difference for IL-17 inhibitors (HR, 0.86; 95% CI, 0.54-1.38) vs TNF inhibitors For IL-12/23 inhibitors, the results persisted in all sensitivity analyses ...

Scientists at the University of California, San Diego School of Medicine have described for the first time a key inhibitory role for the IL-1 signaling pathway in the human innate immune system ...

Previous research has suggested that IL-1 signaling in neurons is involved in sickness behaviors, anxiety, and changes in sleep, but the exact neural circuits involved have not been well-defined.