Explores how inhalational anesthetics trigger general anesthesia through interaction with calcium channel RyR1.

Before 1846, surgery was a crude and brutal undertaking, typically performed on conscious patients lashed to their beds. Then ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for ...

Since their effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general ...

A research team at The University of Tokyo has discovered that inhalational anesthetics activate a protein called type 1 ryanodine receptor (RyR1), ...

A research team at The University of Tokyo has discovered that inhalational anesthetics activate a protein called type 1 ryanodine receptor (RyR1), which contributes to the induction of general ...

Abstract. Background The impact of choosing between inhalational anesthetics and propofol for maintenance anesthesia in liver transplantation or liver resections remains uncertain.. Methods A ...

The research group first confirmed that isoflurane and other inhalational anesthetics activate RyR1 and stimulate calcium release from the endoplasmic reticulum *2. The amino acid residues in RyR1 ...

Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory ...

Paratek Pharmaceuticals, Inc., a biopharmaceutical company focused on providing innovative medical therapies that create positive patient stories in the hospital, community and public health settings, ...