MAC: Minimum alveolar concentration of inhalational anesthetics at steady state that prevents reaction to a standard surgical stimulus (skin incision) in 50 % of patients at 1 atmosphere.

Authors and Disclosures. Pamela Sun Department of Anaesthetics, Pain Medicine & Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, UK Tel.: +44 208 746 8495 Fax ...

Objective To evaluate the short-term efficacy and safety of methoxyflurane for the treatment of acute pain in patients presenting to an emergency department (ED) with minor trauma. Methods STOP! was a ...

Explores how inhalational anesthetics trigger general anesthesia through interaction with calcium channel RyR1.

Cell–cell signaling peptides (e.g., peptide hormones, neuropeptides) are among the largest class of cellular transmitters and regulate a variety of physiological processes. To identify and quantify ...

Before 1846, surgery was a crude and brutal undertaking, typically performed on conscious patients lashed to their beds. Then ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for ...

A new study uncovers the long-elusive mechanism of inhalational anesthetics by identifying the RyR1 calcium channel as a key molecular target.

Since their effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general ...

A research team at The University of Tokyo has discovered that inhalational anesthetics activate a protein called type 1 ryanodine receptor (RyR1), ...

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Rationale Inhalational exposures are associated with risk of developing interstitial lung disease (ILD), yet the relationship between specific exposures and ILD is poorly characterised. Objective ...