To present the pioneering concept, Peer and his team encoded the anti-inflammatory protein interleukin-10 into mRNA and ...

The interleukin (IL)-20 is a subfamily part of the IL-10 family of cytokines that helps the liver respond to damage and disease, they participate in the control of tissue homeostasis, and in the ...

The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 ...

As companies across the pharma and biotech sectors gathered at the annual JPM Healthcare Conference 2025, held from 13 January to 16 January in San Francisco, company presentations gave a view of the ...

Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential. Aim We aimed to ...

4 Tissue Typing Laboratory of the Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark 5 Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark ...

These results demonstrate that the axis of interleukin 12 and gamma interferon provides a survival advantage in vascularized xenografts by delaying or preventing acute vascular rejection caused by ...

Through cytokine screening, we identified that interleukin-1β (IL-1β), a key mediator of inflammation ... Vero E6-ACE2 or Calu-3 cells at 1:1 ratio before adhesion to the 48-well or 96-well plates, ...

1 Clinical Investigation Centre Biotherapy INSERM CIC-1431, University Hospital of Besançon, Besançon, France 2 Fédération Hospitalo-Universitaire INCREASE, University Hospital of Besançon, Besançon, ...

The FDA has granted Fast Track designation to rezpegaldesleukin for the treatment of moderate to severe atopic dermatitis.

Silverberg, J.I., Rosmarin, D., Chovatiya, R.  et al.  The regulatory T cell-selective interleukin-2 receptoragonist rezpegaldesleukin in the treatment of inflammatory ...