Liver fibrosis is a major global health concern, developing as a result of chronic liver diseases (CLDs) such as viral ...

The gene expression and spatial distribution of the immune cells in the tumour microenvironment indicates whether liver cancer will ... which is a carbohydrate on the cell surface.

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.

To address this gap, researchers conducted a series of experiments ... Ammonia Build-Up Kills Liver Cells but Can Be Prevented Using Existing Drug Mar. 7, 2025 — High levels of ammonia kill ...

Increases in RIPK1 and RIPK3 corresponded to increased liver scarring and liver cell death, proving that ammonia directly causes liver injury for the first time. The team then administered two ...

Recent studies have highlighted the potential strategy for pharmacological interventions that modulate immunogenic cell death, suggesting that a deeper understanding of ICD could help guide future ...

Bioartificial liver support systems, granulocyte-colony stimulating factors or stem-cell transplant are in the horizon of medical care of this patient population; however, data are too premature to ...

In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD). Design We constructed a novel hepatocyte-specific PPARα knockout (Pparα hep−/−) mouse model.

Identifying Amphiregulin Sources Using scRNA Analysis: Immune Cell Subsets Driving Hepatic Stellate Cell Activation and Liver Fibrosis in NAFLD/NASH power-ceiling-0e5 ...

Ubiquitin Ligase E3 HUWE1/MULE Targets Transferrin Receptor for Degradation and Suppresses Ferroptosis in Acute Liver Injury. Cell Death and Differentiation. 2022. Vol. 29:1705–1718 Baek K, Krist DT, ...