Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

This study presents important findings on the activity of two compounds, BKC and IBC, isolated from Psoralea corylifolia, which act synergistically to inhibit cancer cell proliferation. Using a ...

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the ...

Additionally, mechanisms underlying DNA sequence alteration have been found to act as predictors of tumorigenesis, as well as directly influence therapy response. Thus, gaining a deeper understanding ...

Based on these results, whether the molecular mechanism of pUL13 inhibition of PKR can inspire treating ... Figure 4 pUL13 phosphorylates H2AX to promote viral replication. The conserved herpesvirus ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ... copied during cell division -- known as DNA replication -- and this introduces permanent mutations ...

Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication. Neurons, however, do not divide. For this reason, they are at ...

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While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ... and copied during cell division—known as DNA replication—and this introduces permanent mutations ...

chiefly because scientists lack the ability to closely observe the intricate process of replication. Attempts to do so have relied on chemicals that damage the DNA structure or strategies that ...

This is where DNA and RNA epigenetics come in: a series of mechanisms that act as "markers" on genes, to control their activity without modifying the DNA or RNA sequence itself. Until now ...