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为解决HTA（卫生技术评估）中Excel队列模型难以捕捉患者异质性导致的偏倚问题，研究人员开发了基于LAMBDA和REDUCE函数的无VBA患者级离散事件仿真（DES）方法。该研究实现了4秒内完成万例患者模拟，与VBA模型结果一致且显著优于传统DICE方法，为HTA决策提供了更透明、高效的技术路径。