In cancer, Cdc37 is phosphorylated by casein kinase 2 (CK2) and then the phosphoprotein binds to various kinase ‘clients’ and to the chaperone Hsp90. Hsp90 facilitates the folding of the clients into ...

ABSTRACT: Soil cadmium (Cd) and lead (Pb) pollution is becoming increasingly serious; heavy metals are accumulating in soil and agricultural products, and vegetables, as an indispensable part of ...

BACKGROUND AND OBJECTIVES: The discovery of the psychoactive agent of Cannabis sativa (tetrahydrocannabinol - THC) in the second half of the 20 th century originated the research that later came to ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

A key concept emerging in the treatment of bladder cancer is the idea of broad immune potentiation. Traditional therapies like BCG may fail in some patients because they stimulate a narrow immune ...

Review publication details benefits of repetitive transcranial magnetic stimulation (rTMS) on Alzheimer’s, including increases in neuroplasticity and other structural and functional second order ...

Allarity Therapeutics, Inc. has announced a research collaboration with the Indiana Biosciences Research Institute (IBRI) to enhance their understanding of stenoparib, a dual PARP and WNT pathway ...

Platinum(II) complexes such as cisplatin, among a few others, are well-known anticancer metal-based drugs approved for clinical use. In spite of their wide acceptance, the respective chemotherapy is ...

"I think [gepotidacin] gives a different side effect profile available to the clinicians, and I think for patients as well, it provides a better, more durable option over time," says Ryan Haumschild, ...

The study provides a valuable showcase of a workflow to perform large-scale characterization of drug mechanisms of action using proteomics in which on-target and off-targets of 166 compounds using ...