A number of proteins regulating this process are mutated in human diseases. We focus on centronuclear myopathy due to mutations in the large GTPase dynamin 2 (DNM2), the first protein shown to ...

Myopathy refers to diseases of skeletal muscles (muscles connected to bone). The condition can be acute (meaning sudden, severe, and short-lasting) or chronic (persistent, recurrent, and often ...

Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of autoimmune diseases with various clinical manifestations, treatment responses, and prognoses. According to the clinical ...

Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle ...