Janelia researchers have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, highlighting how interactions ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), ...

Researchers in Bochum have discovered a control mechanism that may also operate beyond plants. Proteins carrying a "tail anchor" must be inserted into the ER membrane before they can fulfill their ...

A protein notorious for its role in Alzheimer’s disease may hold the key to supercharging the aging immune system, according to new research. Scientists have found that a byproduct of amyloid-beta ...

Scientists have uncovered a surprising way Parkinson’s disease may start: tiny toxic proteins that punch holes in brain cells like revolving doors. Instead of causing instant collapse, these ...

Every day, billions of damaged or unnecessary cells die and are swept away by the immune system’s cleanup crew—phagocytes. But when that clearance falters, dangerous cells can linger, fueling cancer ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Effector mechanisms of the unfolded protein ...

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice. In these autoimmune diseases ...

A protein found in our cells has emerged as a secret weapon against biological aging, acting like a glue to repair damaged DNA and ward off neurological degeneration including that seen in motor ...

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