Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 24 (June 12, 2012), pp. 9420-9425 (6 pages) Protein domains are conspicuous structural units in globular ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints that poorly understood prions may have been the vital missing ingredient ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 12, [Part 2: Biological Sciences] (Dec., 1981), pp. 7820-7824 (5 pages) Tight junctions between cerebral ...

From muscle growth to cellular repair, proteins fuel everything in the body. However, not all proteins are created equal. The ...

Recently identified and long-lasting type of protein misfolding — non-native entanglements — observed in all-atom protein folding simulations. Representative misfolded conformations of the small ...

Protein-degrader structure and function have been captured in unprecedented detail. Protein degraders are recognized as an exciting avenue for drug discovery and development, providing targeted ...