– 53.7% mean splicing correction observed following a single 15 mg/kg dose of PGN-EDODM1, with all patients showing an improvement in splicing – – PGN-EDODM1 was generally well-tolerated at 15 mg/kg, ...

– 53.7% mean splicing correction observed following a single 15 mg/kg dose of PGN-EDODM1, with all patients showing an improvement in splicing – – PGN-EDODM1 was generally well-tolerated at 15 mg/kg, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Drug resistance critically limits the ...

HOUSTON--(BUSINESS WIRE)--Chemelex, a global leader in heat tracing, today announced the launch of the Raychem Elexant 3500i family of electronic thermostats. Based on a configurable hardware platform ...

Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our understanding of RNA splicing, ...

Accurate gene expression requires that the enzyme that polymerizes RNA stops at the proper site (termination). In addition, multiple RNA processing reactions, including removal of intervening ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The fast and transient induction of immediate ...

cDepartment of Biochemistry & Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking ...

The following is a summary of “Roles and mechanisms of aberrant alternative splicing in melanoma – implications for targeted therapy and immunotherapy resistance,” published in the March 2024 issue of ...

Splicing is the stepwise molecular process by which introns are removed from pre-mRNA and exons are joined together to form mature mRNA sequences. The ordering and spatial distribution of these steps ...

Scientists have written a review to discuss emerging research and evidence of the roles of alternative splicing defects in major neurodegenerative diseases. They also summarize the latest advances in ...