Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In ribosome-associated quality control (RQC), ...

From viruses to humans, life makes microproteins that have evaded discovery until now. By Carl Zimmer You could be forgiven for assuming that scientists know how many kinds of proteins exist. After ...

This image highlights two alternatives for the ribosome to be recruited to an mRNA that is still being synthesized by RNA polymerase (RNAP). RNAP (left, red) can directly deliver the mRNA to the entry ...

Gcn2 is a critically important protein kinase of the integrated stress response (ISR) pathway and is conserved from yeast to humans. Although Gcn2 has long been known to interact with 60S subunits, ...

This important paper reveals that one of the major roles of the WDR5 WIN site is to promote ribosome synthesis, and that by attacking the WIN site with inhibitors ribosome attrition occurs creating ...

Cover: Deficiency of death receptor 6 induces precocious myelination in early postnatal development. The extracellular domain of death receptor 6 can be proteolytically released by the metalloprotease ...

New high-resolution images have provided insights into how the large subunit of human ribosomes assembles, advancing our understanding of these essential cellular machines. The findings, which ...

A research team has found that Nourseothricin, an old antibiotic, could be effective against drug-resistant bacteria. Improved purification techniques have identified less toxic forms of the ...

In a recent study published in the journal Nature, researchers examined molecular-level differences in ribosomal translational fidelity between humans and bacteria ...