Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling.

Helicases are dynamic enzymes that play essential roles in DNA and RNA metabolism, transcription, repair, and recombination and are often dysregulated in human diseases. In addition, helicases are ...

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...

Each ATPase contains a QLQ protein interaction domain (QLQ, blue), a helicase SANT-associated domain (HSA ... SNF complexes is the recruitment of these complexes to various genomic loci, yet most of ...

DNA methylation has been shown to play a key role in regulating genes involved in metabolic adaptation during pregnancy, and aberrant DNA methylation has been demonstrated during pregnancy ...

To our knowledge, there are no existing investigations employing a separation protocol resembling the helicase dissociation process of DNA. Helicases break hydrogen bridges in a helicoidal-sequence ...

Other methods for measuring origin activation, such as generation of single-stranded DNA or incorporation of nucleoside analogs, also suffer from this limitation. Distinguishing between firing of the ...

Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis.

The research uncovers the vital role of a protein called ... IIα (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled threads into ...

Although protein-based testing and testing of circulating tumor cells are options, the bulk of promising research in bladder cancer is investigating the role of plasma-based circulating tumor DNA ...

Explore how artificial intelligence (AI) revolutionizes genomics by enhancing gene editing, decoding human DNA, and advancing precision medicine. Learn more about its transformative impact on the ...