The hairpin ribozyme catalyses sequence-specific cleavage of RNA. ... D. M. & Bevilacqua, P. C. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme. Science 287, 1493 ...

Researchers from the Chinese Academy of Sciences (CAS) and their collaborators at Qi Biodesign have developed a strand-specific, CRISPR-free editing system for modifying genomes in the nucleus ...

By fusing a nickase Cas9 with ssDNA-specific deaminases, they have successively developed the cytosine base editor (CBE) and adenine base editor (ABE) systems, which allow efficient C·G-to-T·A ...

Metagenomi Adenine Base Editors (ABEs) demonstrated over 95% genome targetability Simultaneous ABE triplex editing resulted in over 95% protein knockdown in primary T-cells ABE demonstrated highly ...

Base editing is a precise genome editing technology that enables the direct conversion of one base pair to another without inducing double-strand breaks (DSBs) in the DNA.Unlike conventional genome ...

Upon examining the catalyst further, the team found its specific surface area (46 m 2 /g) to be 10 times higher than those of commercially available titanates (1–4 m 2 /g). Prof.