The work tests and revises a 50-year old textbook model, known as the Bloch hypothesis, for the evolution of sterol metabolism in eukaryotic cells.

Researchers from the University of Pittsburgh School of Medicine have linked pulmonary arterial hypertension (PAH), a progressive disease characterized by blood vessel remodeling, with lysosomal ...

A recent study published in Life Metabolism introduced a novel cyclic peptide, DC646, which specifically binds to the co-activator binding site of FXR, thereby blocking co-activator recruitment ...

A recent study published in Life Metabolism introduced a novel cyclic peptide, DC646, which specifically binds to the co-activator binding site of FXR, thereby blocking co-activator recruitment ...

Sterol-regulatory element binding protein 2 (SREBP2), 3-hydroxy-3-methylglutaryl conenzyme A reductase (HMGCR), and squalene epoxidase (SQLE) are key molecules involved in cholesterol biosynthesis ...

Metabolism refers to biochemical processes that occur within any living organism, including humans, to maintain life. These biochemical processes allow the body to grow, reproduce, repair damage ...