During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

SR9009 was found to exert REV-ERB–independent effects on proliferation, metabolism, and gene transcription in 2 different cell types depleted of REV-ERBs. Therefore, effects of these drugs cannot be ...

CAR T-cell therapy as option for diseases of the peripheral nervous system Our work shows that the targeted use of CAR T-cells is possible and of significant clinical benefit, even for severe ...

The T-cell proliferation assay identified a downregulation of anti-donor responses of CD4 (P =.032) and CD8 (P =.016) T cells at 12 months in the intervention cohort compared with the control group.

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

Idaho National Lab partners with Clean Core to test a new thorium-based nuclear fuel that may improve safety, cut waste, and ...

Why I switched to T-Mobile 5G Home Internet I went with T-Mobile for several reasons. DSL was too slow. My next-door neighbor got T-Mobile 5G Home Internet and raved about it.

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.