Figure 1. Multiplex assay design. Image Credit: Sartorius. By integrating the iQue ® Human T Cell Memory Kit with the iQue ® Human T Cell Companion Kits of the user’s choice, up to six ...

Figure 1a. Illustration of the iQue ® spheroid T cell killing assay principles. Image Credit: Sartorius. Spheroids are dissociated at assay endpoint in order to create a single cell suspension ...

CAR T-cell therapy basics. ... proliferation, safety, and efficacy. 1. Key bioanalysis components. ... For more thorough profiling, a combination of assay platforms can be used.

These secondary signals are necessary for T cell activation and require the engagement of proteins on T cells, such as CD28, and other proteins on APCs, including the CD80/CD86 complex. Signal 2 ...

The authors transduced primary human T cells from heathy donors with a lentiviral library containing 12,000 bar-coded genes to determine the effect of each gene on T-cell proliferation.

A sensitive and robust bioanalytical assay for pharmacokinetic analysis of ROR1xCD3 bispecific T cell engager (NVG-111) in a first-in-human study. ... The MSD-ECLA assay was employed to measure ...

Chimeric antigen receptor (CAR) T-cell therapy has been an exciting breakthrough against hematologic cancers. 6 We and others have shown the clinical safety and efficacy of allogeneic CD7 CAR T ...

In two different TCR CD4+ T-cell models, inactivating the gene helped the T cells expand, while the the proliferation of untreated cells quickly stopped, the researchers reported.

The T-cell therapy treatment class, which has transformed the treatment of certain blood cancers, has now reached the solid tumor field thanks to an FDA approval for a first-of-its-kind ...