Instead of fixing one of the many genes that can be mutated, the technique addresses a type of mutation they share, a stop codon that cuts off protein production too soon.

Enter tRNA. "Transfer RNAs are ancient molecules," said Gustavo Caetano-Anollés of the University of Illinois at Urbana-Champaign. "They're molecular fossils." Caetano-Anollés and his colleague ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

A new review highlights the transformative potential of transfer RNA-derived small RNAs (tsRNAs) in the field of liquid biopsy, emphasizing their role as promising biomarkers for a wide range of ...

James Chappell, associate professor of biosciences and bioengineering at Rice University. In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, ...

An abnormal epigenetic modification of RNA could be related to senescence and aging disorders, pointing towards the enzyme methyltransferase-like 1 (METTL1) as a potential therapeutic target.

Professor Zhou's research group focuses on developing and applying new technologies to visualize spatial and temporal distributions of chemical modifications in the mammalian transcriptome at ...

Transfer RNA, more commonly referred to as tRNA, is well known for its key role in translating genetic material into protein. Recent discoveries about fragments of tRNA, which scientists had ...

Replicate Bioscience, a clinical-stage company pioneering novel self-replicating RNA (srRNA) technology for applications across infectious disease, immunology, and other therapeutic areas, and ...