文章中说，急性脑出血的强化降压治疗研究（（INTERACT3）研究表明，实施积极的组合性管理（或称护理包）可改善急性脑出血（ICH）患者的预后功能。然而，对于积极的组合性管理中每个组成部分对获益的相对贡献仍存在不确定性。

Maes团队通过整合近三十年研究进展，揭示外周与中枢免疫失衡（IRS/CIRS系统失调）、脂质代谢异常、氧化应激及肠脑轴相互作用共同构成的病理网络。重点探讨了神经免疫-代谢-氧化应激（neuroimmune-metabolism-oxidative stress, NIMETOX）通路如何介导心理应激、感染和代谢综合征等因素诱发抑郁及自杀行为的机制，并提出“分期-分型”研究框架以解析临床异质性。

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