每个基因敲低实验都是通过CRISPR技术在人类神经祖细胞中逐一进行的，每次敲低都改变了多达2463个其他基因的表达，而且在所有实验中，差异表达基因之间存在显著的趋同性。研究人员通过批量测序神经祖细胞的RNA来评估表达水平，这种方法克服了以往使用脑类器官和死后脑组织研究的局限性。

But a team of researchers led by Kishore Guda, associate professor at the Digestive Health Research Institute at the Case Western Reserve School of Medicine, found a special class of ribonucleic acid ...

Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth. By ...

Alternative RNA splicing is similar to a movie editor cutting and rearranging scenes from the same video to produce distinct ...

The Florida surgeon general in January 2024 called for a halt in the use of COVID mRNA vaccines. And in Texas, Attorney ...

植物病毒作为一类新的病原体被发现已有一个多世纪，当前已成为危害全球农业生产的一类重要病原物，每年造成的经济损失超过600亿美元，目前还没有有效的抗植物病毒药剂。植物病毒百分之八十以上是RNA病毒，它们都编码一个高度保守的RNA复制酶催化合成病毒的基因 ...

此次研究的核心是番茄斑萎病毒，其RNA复制酶的分子量达到330kDa，是已知最大的一种植物病毒RNA复制酶。研究人员通过一系列复杂的表达及纯化技术，成功获得了高纯度的酶样本，并借助冷冻电镜技术捕获到了复制酶多种状态下的三维结构。这一过程使科学家们第一次得以全面了解植物病毒复制酶的激活及抑制机制，为寻求有效的抗病毒药物提供了有力依据。

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Bioengineering professor and The Grainger College of Engineering's Dean, Rashid Bashir, led a team of researchers in a ...

Skyhawk Therapeutics, Inc., a clinical-stage biotechnology company developing novel small molecule therapies designed to ...

Arizona State Retirement System boosted its stake in Avidity Biosciences, Inc. (NASDAQ:RNA – Free Report) by 12.2% in the 4th ...

传统的RNA结构解析方法面临实验成本高昂、预测精度不足等难题。冷冻电镜虽然能够解析高分辨率结构，但要筛选出能够形成稳定构象的RNA序列，仍然需要耗费大量资源。此外，现有算法还依赖于Rfam数据库等二级结构信息。 “RNA有很多家族，此前在解析RNA结构时，科研人员往往不确定应该选择哪些序列进行解析。”复旦大学智能复杂体系实验室研究员、文章共同通讯作者孙思琦解释道，“这就像开‘盲盒’，我们只能猜测哪 ...