Study did not meet primary endpoint in change from baseline in mean daily oral corticosteroid (OCS) dose at week 48, although clinical benefit for efzofitimod observed across multiple study parameters ...

IntegrateRNA's new service enables researchers to generate customized aminoacylated tRNAs, facilitating more accurate and scalable synthesis of proteins containing non-canonical amino acids for ...

More than four billion years ago, Earth was a very different place. Pools of water froze and thawed in cycles, minerals shaped reactions, and molecules bumped into each other by chance. Out of this ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

(A) Bar plot of IARS2 transcription level in different cancer types. (B) TCGA and GTEx databases showed IARS2 transcription level was higher in tumor tissue compared with normal pancreas tissue. (C) ...

Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ. Histidyl-tRNA synthetase and asparaginyl-tRNA ...

Department of Internal Medicine IV, Division of Rheumatology, Osaka Medical and Pharmaceutical University, Osaka, Japan Introduction: This study aimed to identify useful clinical indicators for ...

The manuscript of Davidsen and Sullivan describes an improved tRNA-seq protocol to determine aminoacyl-tRNA levels. The improvements include: (i) optimizing the Whitfeld or oxidation reaction to ...

This article has been corrected. Here, we show for the first time that Sars has indeed acquired a noncanonical function in vertebrates, one that plays a key role in vascular development. Zebrafish ...

The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

Objectives Autoantibodies targeting intracellular proteins are common in various autoimmune diseases. In the context of myositis, the pathologic significance of these autoantibodies has been ...