WEST LAFAYETTE, Ind. — Purdue University experts in the College of Science and Rosen Center for Advanced Computing have launched Molecular Intelligence, a software company whose solutions help ...

Structure of the poxviral core protein A10. The three subunits of the trimer (colored differently) are represented as simulated cryo-EM surfaces in front of a raw cryo-EM micrograph. The cryo-EM ...

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...

Information about macromolecular structure of protein complexes and related cellular and molecular mechanisms can assist the search for vaccines and drug development processes. To obtain such ...

The cryogenic electron microscopy (cryo-EM) field exploded in popularity during the 2010s' "resolution revolution." The 2017 Nobel Prize in Chemistry awarded Jacques Dubochet, Joachim Frank, and ...

The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules ...

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...

Alphaviruses can cause severe human arthritis and encephalitis. During virus infection, structural changes of viral glycoproteins in the acidified endosome trigger virus–host membrane fusion for ...

Researchers at the Indian Institute of Science and collaborators used cryo-EM to decode the molecular architecture of a transporter protein controlling the movement of gamma-aminobutyric acid (GABA).