Cryo-EM single-particle analyses typically require target macromolecule concentration at 0.05~5.0 mg/ml, which is often difficult to achieve. Here, we devise Ma g netic Isolation and Concentration ...

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...

By pinpointing specific structural features associated with disease, researchers can design new or improve existing therapeutics for the treatment of those diseases. To do this, researchers often turn ...

Also featuring micrograph and tomogram denoising with DNNs. ... Python library that enables scripting access to CryoSPARC, a cryo-EM software package. python c image-processing ...

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This article discusses the development of a purpose-built electron cryo-microscope at 100 keV aimed at reducing the cost and complexity of cryo-EM studies on biological structures, thus expanding ...

The most amazing thing about cryo-EM is that it allows us to examine processes that used to be the subject of theory and speculation as we had no means to observe the motion and components ...

Structure of the poxviral core protein A10. The three subunits of the trimer (colored differently) are represented as simulated cryo-EM surfaces in front of a raw cryo-EM micrograph. The cryo-EM ...

To download all available full models, use --all argument. A specific model can be downloaded by using --model-name model_to_download.Currently available models: miffi_v1 - Model trained with ...

FIGURE 1.Floor plan of the cryo-EM suite. The three microscopes (Spirit, Arctica and Krios) are housed in three adjacent rooms. The Artica and Krios are connected to a LN 2 tank located next to the ...