Cryo-Electron Microscopy (Cryo-EM) is an approach that allows the observation of hydrated biological specimens in their native environment at cryogenic temperatures in transmission electron microscopy ...

Training in Cryo-EM is available through MSK’s membership in the New York Structural Biology Center. Dr. Stephen Long, Director of CEMIL, is an expert in structural biology and membrane protein ...

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...

Additionally, cryo-EM is transforming cellular and structural biology by allowing researchers to observe the structure of proteins and biomolecular complexes in-situ within cells and tissue.

In cryo-EM, target particles are suspended in a liquid buffer that’s dabbed onto a small gold disc that has a carbon film layer flecked with tiny holes.

For instance, we have utilized cryo-ET to capture the in situ immune regulation of antimicrobial proteins through liquid-liquid phase separation (Nature 594, 424–429, 2021) and to elucidate the unique ...

WEST LAFAYETTE, Ind. — Purdue University experts in the College of Science and Rosen Center for Advanced Computing have launched Molecular Intelligence, a software company whose solutions help ...

Recent cryo-EM research reveals the dynamic architecture of the pyruvate dehydrogenase complex, enhancing understanding of its role in metabolism and disease. advertisement.

We demonstrate that while map quality is a critical bottleneck, it is possible to sequence antibody variable domains from cryo-EM reconstructions with accuracies of up to 80-90%. While the rate of ...

Cryo-em freezes the funk: How scientists visualized a pungent protein. ScienceDaily. Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 05 / 250527135241.htm.