The natural and overlapping history of tRNA and rRNA reveals that: (1) the tRNA cloverleaf structure unfolded prior to the appearance of a fully functional ribosomal core, (2) the primordial role of ...

Translation is the process by which a protein is synthesized by the ribosome, using a messenger RNA (mRNA) template. tRNA modifications are key regulators of translational reprogramming, although ...

Biologically active RNAs, including transport, ribosomal and small nuclear RNA (tRNA, rRNA, snRNAs) fold into unique structures guided by complementary pairing between nucleotide bases.

The method—dubbed "MapID-tRNA-seq"—allowed researchers to examine all tRNAs and their changes within human cells at once, according to the report. The study focused on transfer RNAs, or tRNAs ...

The first patients have been dosed in a phase 3 trial of an mRNA-based seasonal influenza vaccine developed by Pfizer and BioNTech, which may offer quicker production and greater efficacy than ...

Ethris has entered a strategic partnership with Thermo Fisher Scientific to provide a completely integrated messenger ribonucleic acid (mRNA) solution to biopharmaceutical developers. The ...

Using MapID-tRNA-seq, the researchers were able to map both tRNA modifications and expressions, discovering that some modification profiles from cell to cell largely remain unchanged.

A new and patented method for the production of the important mRNA vaccine component pseudouridine is more efficient, sustainable and cost-effective than the previously used chemical synthesis.

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

According to the CDC, though rare, these side effects most often affect young adult males within 7 days of their second mRNA COVID-19 vaccine dose. Currently approved mRNA vaccines include Moderna ...