a Department of Molecular and Cellular Pathology, University of Dundee, Dundee, UK, b School of Applied Science, South Bank University, London, UK Dr M J Hopkins, MRC Microbiology and Gut Biology ...

Correspondence to Professor Shiv Kumar Sarin, Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi 110070, India; shivsarin{at}gmail.com Objectives Beta-blockers and endoscopic ...

2 Department of Medicine for the Elderly, Leicester General Hospital, Leicester, UK 3 Department of Obstetrics and Gynaecology, Leicester General Hospital, Leicester, UK Correspondence to: Dr S I ...

Correspondence to Dr Andrea Ticinesi, Department of Medicine and Surgery, University of Parma, Parma 43126, Italy; andrea.ticinesi{at}unipr.it Objectives The involvement of the gut microbiota in the ...

Correspondence to Dr Melina Arnold, Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France; arnoldm{at}fellows.iarc.fr Objective The ...

BACKGROUND AND AIMS Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have investigated this risk and reported widely varying rates. METHODS A ...

Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant ...

3 Food Futures National Research Flagship, Commonwealth Scientific and Industrial Research Organisation, Food, Animal and Health Sciences, Adelaide, South Australia, Australia Correspondence to Dr ...

Background Irritable bowel syndrome with diarrhoea (IBS-D) is particularly debilitating due to urgency and episodic incontinence. Some 5-hydroxytryptamine 3 (5-HT3) receptor antagonists (5-HT3RAs) ...

Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites ...

Background—Gut translocation of bacteria has been shown in both animal and human studies. Evidence from animal studies that links bacterial translocation to the development of postoperative sepsis and ...

Objective Solid tumours respond poorly to immune checkpoint inhibitor (ICI) therapies. One major therapeutic obstacle is the immunosuppressive tumour microenvironment (TME). Cancer-associated ...